NS-3-008 HCl ( —— )

产品货号. M21935 CAS No. 1172854-54-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NS-3-008 HCl
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?
产品描述

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
同义词

——
通路

Others
靶点

Other Targets
受体

G0s2
研究领域

——
适应症

——

CAS Number

1172854-54-4
分子量

269.81
分子式

C14H24ClN3
纯度

>98% (HPLC)
溶解度

DMSO:120 mg/ml(444.76 mM; Need ultrasonic);H2O : 125 mg/mL (463.29 mM; Need ultrasonic)
SMILES

Cl.CCCCCCNC(=N)NCc1ccccc1
化学全称

——

1.Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.

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